International Journal of Noncommunicable Diseases

SYSTEMATIC REVIEW ARTICLE
Year
: 2021  |  Volume : 6  |  Issue : 1  |  Page : 10--28

Impact of chronic obstructive pulmonary disease on severity and outcomes in COVID-19 patients: A systematic review


Ashutosh Nath Aggarwal, Ritesh Agarwal, Sahajal Dhooria, Kuruswamy Thurai Prasad, Inderpaul Singh Sehgal, Valliappan Muthu 
 Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Dr. Ashutosh Nath Aggarwal
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012
India

We conducted this systematic review to evaluate whether comorbid chronic obstructive pulmonary disease (COPD) increases the risk of severe disease and adverse outcomes among patients with coronavirus disease (COVID-19). We queried the PubMed and Embase databases for studies indexed till December 2020. We included studies that provided data on severe disease, hospitalization, intensive care unit (ICU) care, need for mechanical ventilation, or mortality among COVID-19 patients with and without COPD. We calculated the relative risk (RR) for each reported outcome of interest from each study and used a random-effects model to summarize our data. We retrieved 997 citations and included 110 studies published in 2020, in our review. Most publications reported the data retrieved from electronic records of retrospective patient cohorts. Only 27 studies were judged to be of high quality. COPD patients with COVID-19 had a significantly higher risk of severe disease (summary RR 2.44, 95% confidence interval [CI] 1.93–3.09), hospitalization (summary RR 1.91, 95% CI 1.70–2.14), ICU admission (summary RR 1.81, 95% CI 1.35–2.43), mechanical ventilation (summary RR 1.75, 95% CI 1.35–2.28), and mortality (summary RR 2.40, 95% CI 1.93–2.51), as compared to COVID-19 patients without COPD. All analyses showed significant between-study heterogeneity. We conclude that comorbid COPD significantly increases the risk of severe disease and adverse outcomes among COVID-19 patients.


How to cite this article:
Aggarwal AN, Agarwal R, Dhooria S, Prasad KT, Sehgal IS, Muthu V. Impact of chronic obstructive pulmonary disease on severity and outcomes in COVID-19 patients: A systematic review.Int J Non-Commun Dis 2021;6:10-28


How to cite this URL:
Aggarwal AN, Agarwal R, Dhooria S, Prasad KT, Sehgal IS, Muthu V. Impact of chronic obstructive pulmonary disease on severity and outcomes in COVID-19 patients: A systematic review. Int J Non-Commun Dis [serial online] 2021 [cited 2021 May 11 ];6:10-28
Available from: https://www.ijncd.org/article.asp?issn=2468-8827;year=2021;volume=6;issue=1;spage=10;epage=28;aulast=Aggarwal;type=0