International Journal of Noncommunicable Diseases

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 4  |  Issue : 4  |  Page : 127--131

Effect of atorvastatin nanoparticles compared to free atrovastatin on plaque properties in rabbit model of atherosclerosis


Anjuman Arora1, Ritika Kondel Bhandari1, Avaneesh Kumar Pandey1, Imran Ibni Gani Rather1, Samir Malhotra1, Alka Bhatia2, Nusrat Shafiq1 
1 Department of Pharmacology, PGIMER, Chandigarh, India
2 Department of Experimental Medicine, PGIMER, Chandigarh, India

Correspondence Address:
Prof. Nusrat Shafiq
Department of Pharmacology, PGIMER, Room No. 4017, 4th Floor, Research Block B, Chandigarh - 160 012
India

Background: Atherosclerosis is a systemic disease affecting the entire arterial tree involving the accumulation of inflammatory cells in the atherosclerotic plaques with larger macrophage-rich areas. Utilizing this property, we aimed to study the effect of atorvastatin nanoparticles given once in a week compared to free atorvastatin given daily on the plaque properties in a rabbit model of atherosclerosis. Materials and Methods: Rabbits were fed with high-cholesterol diet over a period of 2 months. Thereafter, aortic wall tissues were taken for histological changes, and morphometric analysis and plasma samples were taken for the measurement of lipid profile. Results: Our nanoformulation has been effective in improving lipid profile and decreasing plaque content in the aortic wall and showed comparable effect with that of a free drug. Conclusion: Thus, our novelty is the development of sustained-release nanoformulation of atorvastatin having similar pharmacodynamic activity when compared to free atorvastatin.


How to cite this article:
Arora A, Bhandari RK, Pandey AK, Gani Rather II, Malhotra S, Bhatia A, Shafiq N. Effect of atorvastatin nanoparticles compared to free atrovastatin on plaque properties in rabbit model of atherosclerosis.Int J Non-Commun Dis 2019;4:127-131


How to cite this URL:
Arora A, Bhandari RK, Pandey AK, Gani Rather II, Malhotra S, Bhatia A, Shafiq N. Effect of atorvastatin nanoparticles compared to free atrovastatin on plaque properties in rabbit model of atherosclerosis. Int J Non-Commun Dis [serial online] 2019 [cited 2021 Aug 5 ];4:127-131
Available from: https://www.ijncd.org/article.asp?issn=2468-8827;year=2019;volume=4;issue=4;spage=127;epage=131;aulast=Arora;type=0