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ORIGINAL ARTICLE
Year : 2019  |  Volume : 4  |  Issue : 4  |  Page : 127-131

Effect of atorvastatin nanoparticles compared to free atrovastatin on plaque properties in rabbit model of atherosclerosis


1 Department of Pharmacology, PGIMER, Chandigarh, India
2 Department of Experimental Medicine, PGIMER, Chandigarh, India

Correspondence Address:
Prof. Nusrat Shafiq
Department of Pharmacology, PGIMER, Room No. 4017, 4th Floor, Research Block B, Chandigarh - 160 012
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jncd.jncd_27_19

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Background: Atherosclerosis is a systemic disease affecting the entire arterial tree involving the accumulation of inflammatory cells in the atherosclerotic plaques with larger macrophage-rich areas. Utilizing this property, we aimed to study the effect of atorvastatin nanoparticles given once in a week compared to free atorvastatin given daily on the plaque properties in a rabbit model of atherosclerosis. Materials and Methods: Rabbits were fed with high-cholesterol diet over a period of 2 months. Thereafter, aortic wall tissues were taken for histological changes, and morphometric analysis and plasma samples were taken for the measurement of lipid profile. Results: Our nanoformulation has been effective in improving lipid profile and decreasing plaque content in the aortic wall and showed comparable effect with that of a free drug. Conclusion: Thus, our novelty is the development of sustained-release nanoformulation of atorvastatin having similar pharmacodynamic activity when compared to free atorvastatin.


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